Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
Identifieur interne : 000294 ( Main/Exploration ); précédent : 000293; suivant : 000295Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
Auteurs : Alan A. Cohen [Canada] ; Brian K. Kennedy [États-Unis] ; Ulrich Anglas [Canada] ; Anne M. Bronikowski [États-Unis] ; Joris Deelen [Pays-Bas] ; Frédérik Dufour [Canada] ; Gerardo Ferbeyre [Canada] ; Luigi Ferrucci [États-Unis] ; Claudio Franceschi [Russie] ; Daniela Frasca [États-Unis] ; Bertrand Friguet [France] ; Pierrette Gaudreau [Canada] ; Vadim N. Gladyshev [États-Unis] ; Efstathios S. Gonos [Grèce] ; Vera Gorbunova [États-Unis] ; Philipp Gut [Suisse] ; Mikhail Ivanchenko [Russie] ; Véronique Legault [Canada] ; Jean-François Lemaître [France] ; Thomas Liontis [Canada] ; Guang-Hui Liu [République populaire de Chine] ; Mingxin Liu [Canada] ; Andrea B. Maier [Pays-Bas] ; Otávio T. N Brega [Canada] ; Marcel G M. Olde Rikkert [Pays-Bas] ; Graham Pawelec [Canada] ; Sylvie Rheault [Canada] ; Alistair M. Senior [Australie] ; Andreas Simm [Allemagne] ; Sonja Soo [Canada] ; Annika Traa [Canada] ; Svetlana Ukraintseva [États-Unis] ; Quentin Vanhaelen [Hong Kong] ; Jeremy M. Van Raamsdonk [États-Unis] ; Jacek M. Witkowski [Pologne] ; Anatoliy I. Yashin [États-Unis] ; Robert Ziman [Canada] ; Tamàs Fülöp [Canada]Source :
- Mechanisms of ageing and development [ 1872-6216 ] ; 2020.
Abstract
At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as the essence of aging, when it begins, whether aging is programmed or not, whether we currently have a good understanding of aging mechanisms, whether aging is or will be quantifiable, whether aging will be treatable, and whether many non-aging species exist. These disagreements lay bare the urgent need for a more unified and cross-disciplinary paradigm in the biology of aging that will clarify both areas of agreement and disagreement, allowing research to proceed more efficiently. We suggest directions to encourage the emergence of such a paradigm.
DOI: 10.1016/j.mad.2020.111316
PubMed: 32693105
PubMed Central: PMC7603428
Affiliations:
- Allemagne, Australie, Canada, France, Grèce, Hong Kong, Pays-Bas, Pologne, Russie, République populaire de Chine, Suisse, États-Unis
- Auvergne-Rhône-Alpes, Canton de Vaud, Gueldre, Hollande-Méridionale, Hollande-Septentrionale, Iowa, Massachusetts, Nouvelle-Galles du Sud, Québec, Rhône-Alpes, Île-de-France
- Ames (Iowa), Amsterdam, Lausanne, Leyde, Montréal, Nimègue, Paris, Sydney, Villeurbanne
- Université McGill, Université d'État de l'Iowa, Université de Melbourne, Université de Sydney, Université nationale de Singapour
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.</title><author><name sortKey="Cohen, Alan A" sort="Cohen, Alan A" uniqKey="Cohen A" first="Alan A" last="Cohen">Alan A. Cohen</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Alan.Cohen@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Kennedy, Brian K" sort="Kennedy, Brian K" uniqKey="Kennedy B" first="Brian K" last="Kennedy">Brian K. Kennedy</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD 7, 8 Medical Drive, 117596, Singapore; National University Health System (NUHS) Centre for Healthy Longevity, 1E Kent Ridge Road, 119228, Singapore; Singapore Institute of Clinical Sciences, A⁎STAR, Brenner Center for Molecular Medicine, 30 Medical Dr., 117609, Singapore; Buck Institute for Research on Ageing, 8001 Redwood Blvd, Novato, CA, 94945, United States. Electronic address: bkennedy@nus.edu.sg.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD 7, 8 Medical Drive, 117596, Singapore; National University Health System (NUHS) Centre for Healthy Longevity, 1E Kent Ridge Road, 119228, Singapore; Singapore Institute of Clinical Sciences, A⁎STAR, Brenner Center for Molecular Medicine, 30 Medical Dr., 117609, Singapore; Buck Institute for Research on Ageing, 8001 Redwood Blvd, Novato, CA, 94945</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Anglas, Ulrich" sort="Anglas, Ulrich" uniqKey="Anglas U" first="Ulrich" last="Anglas">Ulrich Anglas</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: ulrich.anglas@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bronikowski, Anne M" sort="Bronikowski, Anne M" uniqKey="Bronikowski A" first="Anne M" last="Bronikowski">Anne M. Bronikowski</name><affiliation wicri:level="4"><nlm:affiliation>Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, 50011, United States. Electronic address: abroniko@iastate.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, 50011</wicri:regionArea><orgName type="university">Université d'État de l'Iowa</orgName><placeName><settlement type="city">Ames (Iowa)</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Deelen, Joris" sort="Deelen, Joris" uniqKey="Deelen J" first="Joris" last="Deelen">Joris Deelen</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Biology of Ageing, PO Box 41 06 23, 50866, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands. Electronic address: Joris.Deelen@age.mpg.de.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Max Planck Institute for Biology of Ageing, PO Box 41 06 23, 50866, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dufour, Frederik" sort="Dufour, Frederik" uniqKey="Dufour F" first="Frédérik" last="Dufour">Frédérik Dufour</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Frederik.Dufour@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Ferbeyre, Gerardo" sort="Ferbeyre, Gerardo" uniqKey="Ferbeyre G" first="Gerardo" last="Ferbeyre">Gerardo Ferbeyre</name><affiliation wicri:level="1"><nlm:affiliation>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada. Electronic address: g.ferbeyre@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9</wicri:regionArea><wicri:noRegion>H2X 0A9</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:affiliation>Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225, United States. Electronic address: FerrucciLu@grc.nia.nih.gov.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225</wicri:regionArea><wicri:noRegion>21225</wicri:noRegion></affiliation></author><author><name sortKey="Franceschi, Claudio" sort="Franceschi, Claudio" uniqKey="Franceschi C" first="Claudio" last="Franceschi">Claudio Franceschi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, 33 Via Zamboni, Bologna, 40126 BO, Italy; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Padiglione G, 3 Via Altura, Bologna, 40139, BO, Italy; Department of Applied Mathematics, Institute of Information Technology, Mathematics and Mechanics (ITMM), Lobachevsky State University of Nizhny Novgorod-National Research University (UNN), 23 Gagarin Avenue, 603950, Nizhnij Novgorod, Russia. Electronic address: claudio.franceschi@unibo.it.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, 33 Via Zamboni, Bologna, 40126 BO, Italy; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Padiglione G, 3 Via Altura, Bologna, 40139, BO, Italy; Department of Applied Mathematics, Institute of Information Technology, Mathematics and Mechanics (ITMM), Lobachevsky State University of Nizhny Novgorod-National Research University (UNN), 23 Gagarin Avenue, 603950, Nizhnij Novgorod</wicri:regionArea><wicri:noRegion>Nizhnij Novgorod</wicri:noRegion></affiliation></author><author><name sortKey="Frasca, Daniela" sort="Frasca, Daniela" uniqKey="Frasca D" first="Daniela" last="Frasca">Daniela Frasca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL, 33136, United States. Electronic address: dfrasca@med.miami.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL, 33136</wicri:regionArea><wicri:noRegion>33136</wicri:noRegion></affiliation></author><author><name sortKey="Friguet, Bertrand" sort="Friguet, Bertrand" uniqKey="Friguet B" first="Bertrand" last="Friguet">Bertrand Friguet</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Université, CNRS, INSERM, Institut De Biologie Paris-Seine, Biological Adaptation and Aging, B2A-IBPS, F-75005, Paris, France. Electronic address: bertrand.friguet@sorbonne-universite.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Université, CNRS, INSERM, Institut De Biologie Paris-Seine, Biological Adaptation and Aging, B2A-IBPS, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gaudreau, Pierrette" sort="Gaudreau, Pierrette" uniqKey="Gaudreau P" first="Pierrette" last="Gaudreau">Pierrette Gaudreau</name><affiliation wicri:level="1"><nlm:affiliation>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada; Department of Medicine, Université De Montréal, 2900, Boul. Édouard-Montpetit, Montréal, QC, H3T 1J4, Canada. Electronic address: pierrette.gaudreau@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada; Department of Medicine, Université De Montréal, 2900, Boul. Édouard-Montpetit, Montréal, QC, H3T 1J4</wicri:regionArea><wicri:noRegion>H3T 1J4</wicri:noRegion></affiliation></author><author><name sortKey="Gladyshev, Vadim N" sort="Gladyshev, Vadim N" uniqKey="Gladyshev V" first="Vadim N" last="Gladyshev">Vadim N. Gladyshev</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, United States. Electronic address: vgladyshev@rics.bwh.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115</wicri:regionArea><wicri:noRegion>02115</wicri:noRegion></affiliation></author><author><name sortKey="Gonos, Efstathios S" sort="Gonos, Efstathios S" uniqKey="Gonos E" first="Efstathios S" last="Gonos">Efstathios S. Gonos</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635, Greece. Electronic address: sgonos@eie.gr.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635</wicri:regionArea><wicri:noRegion>11635</wicri:noRegion></affiliation></author><author><name sortKey="Gorbunova, Vera" sort="Gorbunova, Vera" uniqKey="Gorbunova V" first="Vera" last="Gorbunova">Vera Gorbunova</name><affiliation wicri:level="1"><nlm:affiliation>University of Rochester, Department of Biology, Rochester, NY, 14627, United States. Electronic address: vera.gorbunova@rochester.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester, Department of Biology, Rochester, NY, 14627</wicri:regionArea><wicri:noRegion>14627</wicri:noRegion></affiliation></author><author><name sortKey="Gut, Philipp" sort="Gut, Philipp" uniqKey="Gut P" first="Philipp" last="Gut">Philipp Gut</name><affiliation wicri:level="3"><nlm:affiliation>Nestlé Research, Nestlé Institute of Health Sciences, EPFL Innovation Park, 1015, Lausanne, Switzerland. Electronic address: Philipp.Gut@rd.nestle.com.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Nestlé Research, Nestlé Institute of Health Sciences, EPFL Innovation Park, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Ivanchenko, Mikhail" sort="Ivanchenko, Mikhail" uniqKey="Ivanchenko M" first="Mikhail" last="Ivanchenko">Mikhail Ivanchenko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, 603950, Nizhny Novgorod, Russia. Electronic address: ivanchenko.mv@gmail.com.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, 603950, Nizhny Novgorod</wicri:regionArea><wicri:noRegion>Nizhny Novgorod</wicri:noRegion></affiliation></author><author><name sortKey="Legault, Veronique" sort="Legault, Veronique" uniqKey="Legault V" first="Véronique" last="Legault">Véronique Legault</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Veronique.Legault@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Lemaitre, Jean Francois" sort="Lemaitre, Jean Francois" uniqKey="Lemaitre J" first="Jean-François" last="Lemaître">Jean-François Lemaître</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lyon, Université Lyon 1; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, F-69622 Villeurbanne, France. Electronic address: jean-francois.lemaitre@univ-lyon1.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lyon, Université Lyon 1; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, F-69622 Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement></placeName></affiliation></author><author><name sortKey="Liontis, Thomas" sort="Liontis, Thomas" uniqKey="Liontis T" first="Thomas" last="Liontis">Thomas Liontis</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: thomas.liontis@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. Electronic address: ghliu@ioz.ac.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101</wicri:regionArea><wicri:noRegion>100101</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Mingxin" sort="Liu, Mingxin" uniqKey="Liu M" first="Mingxin" last="Liu">Mingxin Liu</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Mingxin.Liu@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B" last="Maier">Andrea B. Maier</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Aged Care, @AgeMelbourne, Royal Melbourne Hospital, University of Melbourne, 34-54 Poplar Rd, Parkville, VIC, 3052, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands. Electronic address: a.b.maier@vu.nl.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medicine and Aged Care, @AgeMelbourne, Royal Melbourne Hospital, University of Melbourne, 34-54 Poplar Rd, Parkville, VIC, 3052, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorststraat 7, 1081 BT, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="N Brega, Otavio T" sort="N Brega, Otavio T" uniqKey="N Brega O" first="Otávio T" last="N Brega">Otávio T. N Brega</name><affiliation wicri:level="1"><nlm:affiliation>Medical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900, Brasília, DF, Brazil; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal (CRIUGM), 4545 Chemin Queen-Mary, Montreal, Qc, H3W 1W5, Canada. Electronic address: otavionobrega@unb.br.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Medical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900, Brasília, DF, Brazil; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal (CRIUGM), 4545 Chemin Queen-Mary, Montreal, Qc, H3W 1W5</wicri:regionArea><wicri:noRegion>H3W 1W5</wicri:noRegion></affiliation></author><author><name sortKey="Olde Rikkert, Marcel G M" sort="Olde Rikkert, Marcel G M" uniqKey="Olde Rikkert M" first="Marcel G M" last="Olde Rikkert">Marcel G M. Olde Rikkert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Radboud University Medical Centre, Reinier Postlaan 4, 6525 GC, Nijmegen, the Netherlands. Electronic address: marcel.olderikkert@radboudumc.nl.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Geriatrics, Radboud University Medical Centre, Reinier Postlaan 4, 6525 GC, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Pawelec, Graham" sort="Pawelec, Graham" uniqKey="Pawelec G" first="Graham" last="Pawelec">Graham Pawelec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, University of Tübingen, Auf Der Morgenstelle 15, 72076 Tübingen, Germany; Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2, Canada. Electronic address: graham.pawelec@uni-tuebingen.de.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Immunology, University of Tübingen, Auf Der Morgenstelle 15, 72076 Tübingen, Germany; Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2</wicri:regionArea><wicri:noRegion>P3E 2H2</wicri:noRegion></affiliation></author><author><name sortKey="Rheault, Sylvie" sort="Rheault, Sylvie" uniqKey="Rheault S" first="Sylvie" last="Rheault">Sylvie Rheault</name><affiliation wicri:level="1"><nlm:affiliation>Département De Neurosciences, Université De Montréal, 2960 Chemin De La Tour, Montréal, QC, H3T 1J4, Canada; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal, 4545 Chemin Queen-Mary, Montréal, QC, H3W 1W4, Canada. Electronic address: sylvie.rheault@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Département De Neurosciences, Université De Montréal, 2960 Chemin De La Tour, Montréal, QC, H3T 1J4, Canada; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal, 4545 Chemin Queen-Mary, Montréal, QC, H3W 1W4</wicri:regionArea><wicri:noRegion>H3W 1W4</wicri:noRegion></affiliation></author><author><name sortKey="Senior, Alistair M" sort="Senior, Alistair M" uniqKey="Senior A" first="Alistair M" last="Senior">Alistair M. Senior</name><affiliation wicri:level="4"><nlm:affiliation>Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, 2006, Australia; School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, 2006, Australia. Electronic address: alistair.senior@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, 2006, Australia; School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Simm, Andreas" sort="Simm, Andreas" uniqKey="Simm A" first="Andreas" last="Simm">Andreas Simm</name><affiliation wicri:level="1"><nlm:affiliation>University Clinic and Outpatient Clinic for Cardiac Surgery, Middle German Heart Centre, University Hospital Halle (Saale), Ernst-Grube Str. 40, D-06120 Halle (Saale), Germany. Electronic address: andreas.simm@uk-halle.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Clinic and Outpatient Clinic for Cardiac Surgery, Middle German Heart Centre, University Hospital Halle (Saale), Ernst-Grube Str. 40, D-06120 Halle (Saale)</wicri:regionArea><wicri:noRegion>06120 Halle (Saale)</wicri:noRegion><wicri:noRegion>06120 Halle (Saale)</wicri:noRegion><wicri:noRegion>D-06120 Halle (Saale)</wicri:noRegion></affiliation></author><author><name sortKey="Soo, Sonja" sort="Soo, Sonja" uniqKey="Soo S" first="Sonja" last="Soo">Sonja Soo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: sonja.soo@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Traa, Annika" sort="Traa, Annika" uniqKey="Traa A" first="Annika" last="Traa">Annika Traa</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: annika.traa@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Ukraintseva, Svetlana" sort="Ukraintseva, Svetlana" uniqKey="Ukraintseva S" first="Svetlana" last="Ukraintseva">Svetlana Ukraintseva</name><affiliation wicri:level="1"><nlm:affiliation>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705, United States. Electronic address: svetlana.ukraintseva@duke.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705</wicri:regionArea><wicri:noRegion>27705</wicri:noRegion></affiliation></author><author><name sortKey="Vanhaelen, Quentin" sort="Vanhaelen, Quentin" uniqKey="Vanhaelen Q" first="Quentin" last="Vanhaelen">Quentin Vanhaelen</name><affiliation wicri:level="1"><nlm:affiliation>Insilico Medicine Hong Kong Ltd., 307A, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Pak Shek Kok, Hong Kong. Electronic address: vanhaelen@insilicomedicine.com.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Insilico Medicine Hong Kong Ltd., 307A, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Pak Shek Kok</wicri:regionArea><wicri:noRegion>Pak Shek Kok</wicri:noRegion></affiliation></author><author><name sortKey="Van Raamsdonk, Jeremy M" sort="Van Raamsdonk, Jeremy M" uniqKey="Van Raamsdonk J" first="Jeremy M" last="Van Raamsdonk">Jeremy M. Van Raamsdonk</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address: jeremy.vanraamsdonk@mcgill.ca.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Witkowski, Jacek M" sort="Witkowski, Jacek M" uniqKey="Witkowski J" first="Jacek M" last="Witkowski">Jacek M. Witkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathophysiology, Medical University of Gdansk, M. Skłodowskiej-Curie 3a Street, 80-210, Gdańsk, Poland. Electronic address: jawit@gumed.edu.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathophysiology, Medical University of Gdansk, M. Skłodowskiej-Curie 3a Street, 80-210, Gdańsk</wicri:regionArea><wicri:noRegion>Gdańsk</wicri:noRegion></affiliation></author><author><name sortKey="Yashin, Anatoliy I" sort="Yashin, Anatoliy I" uniqKey="Yashin A" first="Anatoliy I" last="Yashin">Anatoliy I. Yashin</name><affiliation wicri:level="1"><nlm:affiliation>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705, United States. Electronic address: aiy@duke.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705</wicri:regionArea><wicri:noRegion>27705</wicri:noRegion></affiliation></author><author><name sortKey="Ziman, Robert" sort="Ziman, Robert" uniqKey="Ziman R" first="Robert" last="Ziman">Robert Ziman</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Robert.Ziman@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Fulop, Tamas" sort="Fulop, Tamas" uniqKey="Fulop T" first="Tamàs" last="Fülöp">Tamàs Fülöp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC, J1H 5N4, Canada; Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC, J1H 4C4, Canada. Electronic address: Tamas.Fulop@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC, J1H 5N4, Canada; Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC, J1H 4C4</wicri:regionArea><wicri:noRegion>J1H 4C4</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32693105</idno><idno type="pmid">32693105</idno><idno type="doi">10.1016/j.mad.2020.111316</idno><idno type="pmc">PMC7603428</idno><idno type="wicri:Area/Main/Corpus">000182</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000182</idno><idno type="wicri:Area/Main/Curation">000182</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000182</idno><idno type="wicri:Area/Main/Exploration">000182</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.</title><author><name sortKey="Cohen, Alan A" sort="Cohen, Alan A" uniqKey="Cohen A" first="Alan A" last="Cohen">Alan A. Cohen</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Alan.Cohen@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Kennedy, Brian K" sort="Kennedy, Brian K" uniqKey="Kennedy B" first="Brian K" last="Kennedy">Brian K. Kennedy</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD 7, 8 Medical Drive, 117596, Singapore; National University Health System (NUHS) Centre for Healthy Longevity, 1E Kent Ridge Road, 119228, Singapore; Singapore Institute of Clinical Sciences, A⁎STAR, Brenner Center for Molecular Medicine, 30 Medical Dr., 117609, Singapore; Buck Institute for Research on Ageing, 8001 Redwood Blvd, Novato, CA, 94945, United States. Electronic address: bkennedy@nus.edu.sg.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD 7, 8 Medical Drive, 117596, Singapore; National University Health System (NUHS) Centre for Healthy Longevity, 1E Kent Ridge Road, 119228, Singapore; Singapore Institute of Clinical Sciences, A⁎STAR, Brenner Center for Molecular Medicine, 30 Medical Dr., 117609, Singapore; Buck Institute for Research on Ageing, 8001 Redwood Blvd, Novato, CA, 94945</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Anglas, Ulrich" sort="Anglas, Ulrich" uniqKey="Anglas U" first="Ulrich" last="Anglas">Ulrich Anglas</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: ulrich.anglas@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bronikowski, Anne M" sort="Bronikowski, Anne M" uniqKey="Bronikowski A" first="Anne M" last="Bronikowski">Anne M. Bronikowski</name><affiliation wicri:level="4"><nlm:affiliation>Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, 50011, United States. Electronic address: abroniko@iastate.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, 50011</wicri:regionArea><orgName type="university">Université d'État de l'Iowa</orgName><placeName><settlement type="city">Ames (Iowa)</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Deelen, Joris" sort="Deelen, Joris" uniqKey="Deelen J" first="Joris" last="Deelen">Joris Deelen</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Biology of Ageing, PO Box 41 06 23, 50866, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands. Electronic address: Joris.Deelen@age.mpg.de.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Max Planck Institute for Biology of Ageing, PO Box 41 06 23, 50866, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dufour, Frederik" sort="Dufour, Frederik" uniqKey="Dufour F" first="Frédérik" last="Dufour">Frédérik Dufour</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Frederik.Dufour@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Ferbeyre, Gerardo" sort="Ferbeyre, Gerardo" uniqKey="Ferbeyre G" first="Gerardo" last="Ferbeyre">Gerardo Ferbeyre</name><affiliation wicri:level="1"><nlm:affiliation>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada. Electronic address: g.ferbeyre@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9</wicri:regionArea><wicri:noRegion>H2X 0A9</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation wicri:level="1"><nlm:affiliation>Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225, United States. Electronic address: FerrucciLu@grc.nia.nih.gov.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225</wicri:regionArea><wicri:noRegion>21225</wicri:noRegion></affiliation></author><author><name sortKey="Franceschi, Claudio" sort="Franceschi, Claudio" uniqKey="Franceschi C" first="Claudio" last="Franceschi">Claudio Franceschi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, 33 Via Zamboni, Bologna, 40126 BO, Italy; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Padiglione G, 3 Via Altura, Bologna, 40139, BO, Italy; Department of Applied Mathematics, Institute of Information Technology, Mathematics and Mechanics (ITMM), Lobachevsky State University of Nizhny Novgorod-National Research University (UNN), 23 Gagarin Avenue, 603950, Nizhnij Novgorod, Russia. Electronic address: claudio.franceschi@unibo.it.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, 33 Via Zamboni, Bologna, 40126 BO, Italy; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Padiglione G, 3 Via Altura, Bologna, 40139, BO, Italy; Department of Applied Mathematics, Institute of Information Technology, Mathematics and Mechanics (ITMM), Lobachevsky State University of Nizhny Novgorod-National Research University (UNN), 23 Gagarin Avenue, 603950, Nizhnij Novgorod</wicri:regionArea><wicri:noRegion>Nizhnij Novgorod</wicri:noRegion></affiliation></author><author><name sortKey="Frasca, Daniela" sort="Frasca, Daniela" uniqKey="Frasca D" first="Daniela" last="Frasca">Daniela Frasca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL, 33136, United States. Electronic address: dfrasca@med.miami.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL, 33136</wicri:regionArea><wicri:noRegion>33136</wicri:noRegion></affiliation></author><author><name sortKey="Friguet, Bertrand" sort="Friguet, Bertrand" uniqKey="Friguet B" first="Bertrand" last="Friguet">Bertrand Friguet</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Université, CNRS, INSERM, Institut De Biologie Paris-Seine, Biological Adaptation and Aging, B2A-IBPS, F-75005, Paris, France. Electronic address: bertrand.friguet@sorbonne-universite.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Université, CNRS, INSERM, Institut De Biologie Paris-Seine, Biological Adaptation and Aging, B2A-IBPS, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gaudreau, Pierrette" sort="Gaudreau, Pierrette" uniqKey="Gaudreau P" first="Pierrette" last="Gaudreau">Pierrette Gaudreau</name><affiliation wicri:level="1"><nlm:affiliation>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada; Department of Medicine, Université De Montréal, 2900, Boul. Édouard-Montpetit, Montréal, QC, H3T 1J4, Canada. Electronic address: pierrette.gaudreau@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada; Department of Medicine, Université De Montréal, 2900, Boul. Édouard-Montpetit, Montréal, QC, H3T 1J4</wicri:regionArea><wicri:noRegion>H3T 1J4</wicri:noRegion></affiliation></author><author><name sortKey="Gladyshev, Vadim N" sort="Gladyshev, Vadim N" uniqKey="Gladyshev V" first="Vadim N" last="Gladyshev">Vadim N. Gladyshev</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, United States. Electronic address: vgladyshev@rics.bwh.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115</wicri:regionArea><wicri:noRegion>02115</wicri:noRegion></affiliation></author><author><name sortKey="Gonos, Efstathios S" sort="Gonos, Efstathios S" uniqKey="Gonos E" first="Efstathios S" last="Gonos">Efstathios S. Gonos</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635, Greece. Electronic address: sgonos@eie.gr.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635</wicri:regionArea><wicri:noRegion>11635</wicri:noRegion></affiliation></author><author><name sortKey="Gorbunova, Vera" sort="Gorbunova, Vera" uniqKey="Gorbunova V" first="Vera" last="Gorbunova">Vera Gorbunova</name><affiliation wicri:level="1"><nlm:affiliation>University of Rochester, Department of Biology, Rochester, NY, 14627, United States. Electronic address: vera.gorbunova@rochester.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester, Department of Biology, Rochester, NY, 14627</wicri:regionArea><wicri:noRegion>14627</wicri:noRegion></affiliation></author><author><name sortKey="Gut, Philipp" sort="Gut, Philipp" uniqKey="Gut P" first="Philipp" last="Gut">Philipp Gut</name><affiliation wicri:level="3"><nlm:affiliation>Nestlé Research, Nestlé Institute of Health Sciences, EPFL Innovation Park, 1015, Lausanne, Switzerland. Electronic address: Philipp.Gut@rd.nestle.com.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Nestlé Research, Nestlé Institute of Health Sciences, EPFL Innovation Park, 1015, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Ivanchenko, Mikhail" sort="Ivanchenko, Mikhail" uniqKey="Ivanchenko M" first="Mikhail" last="Ivanchenko">Mikhail Ivanchenko</name><affiliation wicri:level="1"><nlm:affiliation>Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, 603950, Nizhny Novgorod, Russia. Electronic address: ivanchenko.mv@gmail.com.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, 603950, Nizhny Novgorod</wicri:regionArea><wicri:noRegion>Nizhny Novgorod</wicri:noRegion></affiliation></author><author><name sortKey="Legault, Veronique" sort="Legault, Veronique" uniqKey="Legault V" first="Véronique" last="Legault">Véronique Legault</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Veronique.Legault@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Lemaitre, Jean Francois" sort="Lemaitre, Jean Francois" uniqKey="Lemaitre J" first="Jean-François" last="Lemaître">Jean-François Lemaître</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lyon, Université Lyon 1; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, F-69622 Villeurbanne, France. Electronic address: jean-francois.lemaitre@univ-lyon1.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lyon, Université Lyon 1; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, F-69622 Villeurbanne</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Villeurbanne</settlement></placeName></affiliation></author><author><name sortKey="Liontis, Thomas" sort="Liontis, Thomas" uniqKey="Liontis T" first="Thomas" last="Liontis">Thomas Liontis</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: thomas.liontis@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. Electronic address: ghliu@ioz.ac.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101</wicri:regionArea><wicri:noRegion>100101</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Mingxin" sort="Liu, Mingxin" uniqKey="Liu M" first="Mingxin" last="Liu">Mingxin Liu</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Mingxin.Liu@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B" last="Maier">Andrea B. Maier</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Aged Care, @AgeMelbourne, Royal Melbourne Hospital, University of Melbourne, 34-54 Poplar Rd, Parkville, VIC, 3052, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands. Electronic address: a.b.maier@vu.nl.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medicine and Aged Care, @AgeMelbourne, Royal Melbourne Hospital, University of Melbourne, 34-54 Poplar Rd, Parkville, VIC, 3052, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorststraat 7, 1081 BT, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="N Brega, Otavio T" sort="N Brega, Otavio T" uniqKey="N Brega O" first="Otávio T" last="N Brega">Otávio T. N Brega</name><affiliation wicri:level="1"><nlm:affiliation>Medical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900, Brasília, DF, Brazil; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal (CRIUGM), 4545 Chemin Queen-Mary, Montreal, Qc, H3W 1W5, Canada. Electronic address: otavionobrega@unb.br.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Medical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900, Brasília, DF, Brazil; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal (CRIUGM), 4545 Chemin Queen-Mary, Montreal, Qc, H3W 1W5</wicri:regionArea><wicri:noRegion>H3W 1W5</wicri:noRegion></affiliation></author><author><name sortKey="Olde Rikkert, Marcel G M" sort="Olde Rikkert, Marcel G M" uniqKey="Olde Rikkert M" first="Marcel G M" last="Olde Rikkert">Marcel G M. Olde Rikkert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Radboud University Medical Centre, Reinier Postlaan 4, 6525 GC, Nijmegen, the Netherlands. Electronic address: marcel.olderikkert@radboudumc.nl.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Geriatrics, Radboud University Medical Centre, Reinier Postlaan 4, 6525 GC, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Pawelec, Graham" sort="Pawelec, Graham" uniqKey="Pawelec G" first="Graham" last="Pawelec">Graham Pawelec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, University of Tübingen, Auf Der Morgenstelle 15, 72076 Tübingen, Germany; Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2, Canada. Electronic address: graham.pawelec@uni-tuebingen.de.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Immunology, University of Tübingen, Auf Der Morgenstelle 15, 72076 Tübingen, Germany; Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2</wicri:regionArea><wicri:noRegion>P3E 2H2</wicri:noRegion></affiliation></author><author><name sortKey="Rheault, Sylvie" sort="Rheault, Sylvie" uniqKey="Rheault S" first="Sylvie" last="Rheault">Sylvie Rheault</name><affiliation wicri:level="1"><nlm:affiliation>Département De Neurosciences, Université De Montréal, 2960 Chemin De La Tour, Montréal, QC, H3T 1J4, Canada; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal, 4545 Chemin Queen-Mary, Montréal, QC, H3W 1W4, Canada. Electronic address: sylvie.rheault@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Département De Neurosciences, Université De Montréal, 2960 Chemin De La Tour, Montréal, QC, H3T 1J4, Canada; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal, 4545 Chemin Queen-Mary, Montréal, QC, H3W 1W4</wicri:regionArea><wicri:noRegion>H3W 1W4</wicri:noRegion></affiliation></author><author><name sortKey="Senior, Alistair M" sort="Senior, Alistair M" uniqKey="Senior A" first="Alistair M" last="Senior">Alistair M. Senior</name><affiliation wicri:level="4"><nlm:affiliation>Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, 2006, Australia; School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, 2006, Australia. Electronic address: alistair.senior@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, 2006, Australia; School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Simm, Andreas" sort="Simm, Andreas" uniqKey="Simm A" first="Andreas" last="Simm">Andreas Simm</name><affiliation wicri:level="1"><nlm:affiliation>University Clinic and Outpatient Clinic for Cardiac Surgery, Middle German Heart Centre, University Hospital Halle (Saale), Ernst-Grube Str. 40, D-06120 Halle (Saale), Germany. Electronic address: andreas.simm@uk-halle.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Clinic and Outpatient Clinic for Cardiac Surgery, Middle German Heart Centre, University Hospital Halle (Saale), Ernst-Grube Str. 40, D-06120 Halle (Saale)</wicri:regionArea><wicri:noRegion>06120 Halle (Saale)</wicri:noRegion><wicri:noRegion>06120 Halle (Saale)</wicri:noRegion><wicri:noRegion>D-06120 Halle (Saale)</wicri:noRegion></affiliation></author><author><name sortKey="Soo, Sonja" sort="Soo, Sonja" uniqKey="Soo S" first="Sonja" last="Soo">Sonja Soo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: sonja.soo@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Traa, Annika" sort="Traa, Annika" uniqKey="Traa A" first="Annika" last="Traa">Annika Traa</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: annika.traa@mail.mcgill.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Ukraintseva, Svetlana" sort="Ukraintseva, Svetlana" uniqKey="Ukraintseva S" first="Svetlana" last="Ukraintseva">Svetlana Ukraintseva</name><affiliation wicri:level="1"><nlm:affiliation>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705, United States. Electronic address: svetlana.ukraintseva@duke.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705</wicri:regionArea><wicri:noRegion>27705</wicri:noRegion></affiliation></author><author><name sortKey="Vanhaelen, Quentin" sort="Vanhaelen, Quentin" uniqKey="Vanhaelen Q" first="Quentin" last="Vanhaelen">Quentin Vanhaelen</name><affiliation wicri:level="1"><nlm:affiliation>Insilico Medicine Hong Kong Ltd., 307A, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Pak Shek Kok, Hong Kong. Electronic address: vanhaelen@insilicomedicine.com.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Insilico Medicine Hong Kong Ltd., 307A, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Pak Shek Kok</wicri:regionArea><wicri:noRegion>Pak Shek Kok</wicri:noRegion></affiliation></author><author><name sortKey="Van Raamsdonk, Jeremy M" sort="Van Raamsdonk, Jeremy M" uniqKey="Van Raamsdonk J" first="Jeremy M" last="Van Raamsdonk">Jeremy M. Van Raamsdonk</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address: jeremy.vanraamsdonk@mcgill.ca.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Witkowski, Jacek M" sort="Witkowski, Jacek M" uniqKey="Witkowski J" first="Jacek M" last="Witkowski">Jacek M. Witkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathophysiology, Medical University of Gdansk, M. Skłodowskiej-Curie 3a Street, 80-210, Gdańsk, Poland. Electronic address: jawit@gumed.edu.pl.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathophysiology, Medical University of Gdansk, M. Skłodowskiej-Curie 3a Street, 80-210, Gdańsk</wicri:regionArea><wicri:noRegion>Gdańsk</wicri:noRegion></affiliation></author><author><name sortKey="Yashin, Anatoliy I" sort="Yashin, Anatoliy I" uniqKey="Yashin A" first="Anatoliy I" last="Yashin">Anatoliy I. Yashin</name><affiliation wicri:level="1"><nlm:affiliation>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705, United States. Electronic address: aiy@duke.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705</wicri:regionArea><wicri:noRegion>27705</wicri:noRegion></affiliation></author><author><name sortKey="Ziman, Robert" sort="Ziman, Robert" uniqKey="Ziman R" first="Robert" last="Ziman">Robert Ziman</name><affiliation wicri:level="1"><nlm:affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Robert.Ziman@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Fulop, Tamas" sort="Fulop, Tamas" uniqKey="Fulop T" first="Tamàs" last="Fülöp">Tamàs Fülöp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC, J1H 5N4, Canada; Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC, J1H 4C4, Canada. Electronic address: Tamas.Fulop@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC, J1H 5N4, Canada; Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC, J1H 4C4</wicri:regionArea><wicri:noRegion>J1H 4C4</wicri:noRegion></affiliation></author></analytic><series><title level="j">Mechanisms of ageing and development</title><idno type="eISSN">1872-6216</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as the essence of aging, when it begins, whether aging is programmed or not, whether we currently have a good understanding of aging mechanisms, whether aging is or will be quantifiable, whether aging will be treatable, and whether many non-aging species exist. These disagreements lay bare the urgent need for a more unified and cross-disciplinary paradigm in the biology of aging that will clarify both areas of agreement and disagreement, allowing research to proceed more efficiently. We suggest directions to encourage the emergence of such a paradigm.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32693105</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-6216</ISSN><JournalIssue CitedMedium="Internet"><Volume>191</Volume><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Mechanisms of ageing and development</Title><ISOAbbreviation>Mech Ageing Dev</ISOAbbreviation></Journal><ArticleTitle>Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.</ArticleTitle><Pagination><MedlinePgn>111316</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0047-6374(20)30112-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.mad.2020.111316</ELocationID><Abstract><AbstractText>At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as the essence of aging, when it begins, whether aging is programmed or not, whether we currently have a good understanding of aging mechanisms, whether aging is or will be quantifiable, whether aging will be treatable, and whether many non-aging species exist. These disagreements lay bare the urgent need for a more unified and cross-disciplinary paradigm in the biology of aging that will clarify both areas of agreement and disagreement, allowing research to proceed more efficiently. We suggest directions to encourage the emergence of such a paradigm.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Alan A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Alan.Cohen@USherbrooke.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kennedy</LastName><ForeName>Brian K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD 7, 8 Medical Drive, 117596, Singapore; National University Health System (NUHS) Centre for Healthy Longevity, 1E Kent Ridge Road, 119228, Singapore; Singapore Institute of Clinical Sciences, A⁎STAR, Brenner Center for Molecular Medicine, 30 Medical Dr., 117609, Singapore; Buck Institute for Research on Ageing, 8001 Redwood Blvd, Novato, CA, 94945, United States. Electronic address: bkennedy@nus.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anglas</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: ulrich.anglas@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bronikowski</LastName><ForeName>Anne M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, 50011, United States. Electronic address: abroniko@iastate.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deelen</LastName><ForeName>Joris</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Max Planck Institute for Biology of Ageing, PO Box 41 06 23, 50866, Cologne, Germany; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands. Electronic address: Joris.Deelen@age.mpg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dufour</LastName><ForeName>Frédérik</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Frederik.Dufour@USherbrooke.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferbeyre</LastName><ForeName>Gerardo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada. Electronic address: g.ferbeyre@umontreal.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrucci</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225, United States. Electronic address: FerrucciLu@grc.nia.nih.gov.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franceschi</LastName><ForeName>Claudio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, 33 Via Zamboni, Bologna, 40126 BO, Italy; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Padiglione G, 3 Via Altura, Bologna, 40139, BO, Italy; Department of Applied Mathematics, Institute of Information Technology, Mathematics and Mechanics (ITMM), Lobachevsky State University of Nizhny Novgorod-National Research University (UNN), 23 Gagarin Avenue, 603950, Nizhnij Novgorod, Russia. Electronic address: claudio.franceschi@unibo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frasca</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL, 33136, United States. Electronic address: dfrasca@med.miami.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friguet</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Sorbonne Université, CNRS, INSERM, Institut De Biologie Paris-Seine, Biological Adaptation and Aging, B2A-IBPS, F-75005, Paris, France. Electronic address: bertrand.friguet@sorbonne-universite.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaudreau</LastName><ForeName>Pierrette</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre De Recherche Du Centre Hospitalier De l'Université De Montréal (CRCHUM), 900 Saint-Denis St, Montréal, QC, H2X 0A9, Canada; Department of Medicine, Université De Montréal, 2900, Boul. Édouard-Montpetit, Montréal, QC, H3T 1J4, Canada. Electronic address: pierrette.gaudreau@umontreal.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gladyshev</LastName><ForeName>Vadim N</ForeName><Initials>VN</Initials><AffiliationInfo><Affiliation>Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, United States. Electronic address: vgladyshev@rics.bwh.harvard.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonos</LastName><ForeName>Efstathios S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635, Greece. Electronic address: sgonos@eie.gr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorbunova</LastName><ForeName>Vera</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>University of Rochester, Department of Biology, Rochester, NY, 14627, United States. Electronic address: vera.gorbunova@rochester.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gut</LastName><ForeName>Philipp</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Nestlé Research, Nestlé Institute of Health Sciences, EPFL Innovation Park, 1015, Lausanne, Switzerland. Electronic address: Philipp.Gut@rd.nestle.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivanchenko</LastName><ForeName>Mikhail</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, 603950, Nizhny Novgorod, Russia. Electronic address: ivanchenko.mv@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Legault</LastName><ForeName>Véronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Veronique.Legault@USherbrooke.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemaître</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Université de Lyon, Université Lyon 1; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, F-69622 Villeurbanne, France. Electronic address: jean-francois.lemaitre@univ-lyon1.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liontis</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: thomas.liontis@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Guang-Hui</ForeName><Initials>GH</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China. Electronic address: ghliu@ioz.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Mingxin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Mingxin.Liu@USherbrooke.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maier</LastName><ForeName>Andrea B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Department of Medicine and Aged Care, @AgeMelbourne, Royal Melbourne Hospital, University of Melbourne, 34-54 Poplar Rd, Parkville, VIC, 3052, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands. Electronic address: a.b.maier@vu.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nóbrega</LastName><ForeName>Otávio T</ForeName><Initials>OT</Initials><AffiliationInfo><Affiliation>Medical Centre for the Elderly, University Hospital, University of Brasília (UnB), 70910-900, Brasília, DF, Brazil; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal (CRIUGM), 4545 Chemin Queen-Mary, Montreal, Qc, H3W 1W5, Canada. Electronic address: otavionobrega@unb.br.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olde Rikkert</LastName><ForeName>Marcel G M</ForeName><Initials>MGM</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Radboud University Medical Centre, Reinier Postlaan 4, 6525 GC, Nijmegen, the Netherlands. Electronic address: marcel.olderikkert@radboudumc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pawelec</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Immunology, University of Tübingen, Auf Der Morgenstelle 15, 72076 Tübingen, Germany; Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2, Canada. Electronic address: graham.pawelec@uni-tuebingen.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rheault</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Département De Neurosciences, Université De Montréal, 2960 Chemin De La Tour, Montréal, QC, H3T 1J4, Canada; Centre De Recherche De l'Institut Universitaire De Gériatrie De Montréal, 4545 Chemin Queen-Mary, Montréal, QC, H3W 1W4, Canada. Electronic address: sylvie.rheault@umontreal.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senior</LastName><ForeName>Alistair M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, 2006, Australia; School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, 2006, Australia. Electronic address: alistair.senior@sydney.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simm</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University Clinic and Outpatient Clinic for Cardiac Surgery, Middle German Heart Centre, University Hospital Halle (Saale), Ernst-Grube Str. 40, D-06120 Halle (Saale), Germany. Electronic address: andreas.simm@uk-halle.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soo</LastName><ForeName>Sonja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: sonja.soo@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Traa</LastName><ForeName>Annika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: annika.traa@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ukraintseva</LastName><ForeName>Svetlana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705, United States. Electronic address: svetlana.ukraintseva@duke.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vanhaelen</LastName><ForeName>Quentin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Insilico Medicine Hong Kong Ltd., 307A, Core Building 1, 1 Science Park East Avenue, Hong Kong Science Park, Pak Shek Kok, Hong Kong. Electronic address: vanhaelen@insilicomedicine.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Raamsdonk</LastName><ForeName>Jeremy M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address: jeremy.vanraamsdonk@mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witkowski</LastName><ForeName>Jacek M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Pathophysiology, Medical University of Gdansk, M. Skłodowskiej-Curie 3a Street, 80-210, Gdańsk, Poland. Electronic address: jawit@gumed.edu.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yashin</LastName><ForeName>Anatoliy I</ForeName><Initials>AI</Initials><AffiliationInfo><Affiliation>Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, 2024W. Main St, Durham, NC, 27705, United States. Electronic address: aiy@duke.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziman</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Groupe De Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada. Electronic address: Robert.Ziman@USherbrooke.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fülöp</LastName><ForeName>Tamàs</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC, J1H 5N4, Canada; Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC, J1H 4C4, Canada. Electronic address: Tamas.Fulop@USherbrooke.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R37 AG023717</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 AG059719</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG023717</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AG063893</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG070487</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>RF1 AG046860</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG062623</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Mech Ageing Dev</MedlineTA><NlmUniqueID>0347227</NlmUniqueID><ISSNLinking>0047-6374</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aged</Keyword><Keyword MajorTopicYN="N">Aging</Keyword><Keyword MajorTopicYN="N">Aging interventions</Keyword><Keyword MajorTopicYN="N">Aging mechanisms</Keyword><Keyword MajorTopicYN="N">Aging paradigm</Keyword><Keyword MajorTopicYN="N">Biology of aging</Keyword><Keyword MajorTopicYN="N">Epidemiology of aging</Keyword><Keyword MajorTopicYN="N">Evolution of aging</Keyword><Keyword MajorTopicYN="N">Philosophy of science</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>10</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32693105</ArticleId><ArticleId IdType="pii">S0047-6374(20)30112-3</ArticleId><ArticleId IdType="doi">10.1016/j.mad.2020.111316</ArticleId><ArticleId IdType="pmc">PMC7603428</ArticleId><ArticleId IdType="mid">NIHMS1626714</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10</Citation><ArticleIdList><ArticleId IdType="pubmed">26150497</ArticleId></ArticleIdList></Reference><Reference><Citation>Gerontology. 2017;63(5):426-431</Citation><ArticleIdList><ArticleId IdType="pubmed">28538216</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2013 Jun 6;153(6):1194-217</Citation><ArticleIdList><ArticleId IdType="pubmed">23746838</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging Cell. 2016 Dec;15(6):986-998</Citation><ArticleIdList><ArticleId IdType="pubmed">27534524</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging (Albany NY). 2015 Dec;7(12):1171-84</Citation><ArticleIdList><ArticleId IdType="pubmed">26729707</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2019 Nov 1;366(6465):576-578</Citation><ArticleIdList><ArticleId IdType="pubmed">31672885</ArticleId></ArticleIdList></Reference><Reference><Citation>Mech Ageing Dev. 2020 Sep 16;192:111344</Citation><ArticleIdList><ArticleId IdType="pubmed">32949595</ArticleId></ArticleIdList></Reference><Reference><Citation>Geroscience. 2018 Dec;40(5-6):419-436</Citation><ArticleIdList><ArticleId IdType="pubmed">30151729</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2013 Dec 15;12(24):3736-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24240128</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Rep. 2019 Dec 24;29(13):4276-4284.e3</Citation><ArticleIdList><ArticleId IdType="pubmed">31875539</ArticleId></ArticleIdList></Reference><Reference><Citation>Evolution. 2017 Dec;71(12):2768-2785</Citation><ArticleIdList><ArticleId IdType="pubmed">29053173</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2019 Jul 11;178(2):385-399.e20</Citation><ArticleIdList><ArticleId IdType="pubmed">31257025</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2014 Jan 9;505(7482):169-73</Citation><ArticleIdList><ArticleId IdType="pubmed">24317695</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2017 Apr 21;292(16):6452-6460</Citation><ArticleIdList><ArticleId IdType="pubmed">28264931</ArticleId></ArticleIdList></Reference><Reference><Citation>Biogerontology. 2016 Feb;17(1):205-20</Citation><ArticleIdList><ArticleId IdType="pubmed">25991473</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging Cell. 2016 Aug;15(4):594-602</Citation><ArticleIdList><ArticleId IdType="pubmed">27060562</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2014 Nov 6;159(4):709-13</Citation><ArticleIdList><ArticleId IdType="pubmed">25417146</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochemistry (Mosc). 2012 Jul;77(7):729-32</Citation><ArticleIdList><ArticleId IdType="pubmed">22817536</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comp Pathol. 2010 Jan;142 Suppl 1:S10-21</Citation><ArticleIdList><ArticleId IdType="pubmed">19962715</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74</Citation><ArticleIdList><ArticleId IdType="pubmed">23213031</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2013;14(10):R115</Citation><ArticleIdList><ArticleId IdType="pubmed">24138928</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2014 Feb 1;20(4):727-31</Citation><ArticleIdList><ArticleId IdType="pubmed">24159899</ArticleId></ArticleIdList></Reference><Reference><Citation>Acad Med. 2020 May;95(5):686-689</Citation><ArticleIdList><ArticleId IdType="pubmed">31876567</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Grèce</li><li>Hong Kong</li><li>Pays-Bas</li><li>Pologne</li><li>Russie</li><li>République populaire de Chine</li><li>Suisse</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Canton de Vaud</li><li>Gueldre</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Iowa</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Québec</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Ames (Iowa)</li><li>Amsterdam</li><li>Lausanne</li><li>Leyde</li><li>Montréal</li><li>Nimègue</li><li>Paris</li><li>Sydney</li><li>Villeurbanne</li></settlement><orgName><li>Université McGill</li><li>Université d'État de l'Iowa</li><li>Université de Melbourne</li><li>Université de Sydney</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Cohen, Alan A" sort="Cohen, Alan A" uniqKey="Cohen A" first="Alan A" last="Cohen">Alan A. Cohen</name></noRegion><name sortKey="Anglas, Ulrich" sort="Anglas, Ulrich" uniqKey="Anglas U" first="Ulrich" last="Anglas">Ulrich Anglas</name><name sortKey="Dufour, Frederik" sort="Dufour, Frederik" uniqKey="Dufour F" first="Frédérik" last="Dufour">Frédérik Dufour</name><name sortKey="Ferbeyre, Gerardo" sort="Ferbeyre, Gerardo" uniqKey="Ferbeyre G" first="Gerardo" last="Ferbeyre">Gerardo Ferbeyre</name><name sortKey="Fulop, Tamas" sort="Fulop, Tamas" uniqKey="Fulop T" first="Tamàs" last="Fülöp">Tamàs Fülöp</name><name sortKey="Gaudreau, Pierrette" sort="Gaudreau, Pierrette" uniqKey="Gaudreau P" first="Pierrette" last="Gaudreau">Pierrette Gaudreau</name><name sortKey="Legault, Veronique" sort="Legault, Veronique" uniqKey="Legault V" first="Véronique" last="Legault">Véronique Legault</name><name sortKey="Liontis, Thomas" sort="Liontis, Thomas" uniqKey="Liontis T" first="Thomas" last="Liontis">Thomas Liontis</name><name sortKey="Liu, Mingxin" sort="Liu, Mingxin" uniqKey="Liu M" first="Mingxin" last="Liu">Mingxin Liu</name><name sortKey="N Brega, Otavio T" sort="N Brega, Otavio T" uniqKey="N Brega O" first="Otávio T" last="N Brega">Otávio T. N Brega</name><name sortKey="Pawelec, Graham" sort="Pawelec, Graham" uniqKey="Pawelec G" first="Graham" last="Pawelec">Graham Pawelec</name><name sortKey="Rheault, Sylvie" sort="Rheault, Sylvie" uniqKey="Rheault S" first="Sylvie" last="Rheault">Sylvie Rheault</name><name sortKey="Soo, Sonja" sort="Soo, Sonja" uniqKey="Soo S" first="Sonja" last="Soo">Sonja Soo</name><name sortKey="Traa, Annika" sort="Traa, Annika" uniqKey="Traa A" first="Annika" last="Traa">Annika Traa</name><name sortKey="Ziman, Robert" sort="Ziman, Robert" uniqKey="Ziman R" first="Robert" last="Ziman">Robert Ziman</name></country><country name="États-Unis"><noRegion><name sortKey="Kennedy, Brian K" sort="Kennedy, Brian K" uniqKey="Kennedy B" first="Brian K" last="Kennedy">Brian K. Kennedy</name></noRegion><name sortKey="Bronikowski, Anne M" sort="Bronikowski, Anne M" uniqKey="Bronikowski A" first="Anne M" last="Bronikowski">Anne M. Bronikowski</name><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><name sortKey="Frasca, Daniela" sort="Frasca, Daniela" uniqKey="Frasca D" first="Daniela" last="Frasca">Daniela Frasca</name><name sortKey="Gladyshev, Vadim N" sort="Gladyshev, Vadim N" uniqKey="Gladyshev V" first="Vadim N" last="Gladyshev">Vadim N. Gladyshev</name><name sortKey="Gorbunova, Vera" sort="Gorbunova, Vera" uniqKey="Gorbunova V" first="Vera" last="Gorbunova">Vera Gorbunova</name><name sortKey="Ukraintseva, Svetlana" sort="Ukraintseva, Svetlana" uniqKey="Ukraintseva S" first="Svetlana" last="Ukraintseva">Svetlana Ukraintseva</name><name sortKey="Van Raamsdonk, Jeremy M" sort="Van Raamsdonk, Jeremy M" uniqKey="Van Raamsdonk J" first="Jeremy M" last="Van Raamsdonk">Jeremy M. Van Raamsdonk</name><name sortKey="Yashin, Anatoliy I" sort="Yashin, Anatoliy I" uniqKey="Yashin A" first="Anatoliy I" last="Yashin">Anatoliy I. Yashin</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Deelen, Joris" sort="Deelen, Joris" uniqKey="Deelen J" first="Joris" last="Deelen">Joris Deelen</name></region><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B" last="Maier">Andrea B. Maier</name><name sortKey="Olde Rikkert, Marcel G M" sort="Olde Rikkert, Marcel G M" uniqKey="Olde Rikkert M" first="Marcel G M" last="Olde Rikkert">Marcel G M. Olde Rikkert</name></country><country name="Russie"><noRegion><name sortKey="Franceschi, Claudio" sort="Franceschi, Claudio" uniqKey="Franceschi C" first="Claudio" last="Franceschi">Claudio Franceschi</name></noRegion><name sortKey="Ivanchenko, Mikhail" sort="Ivanchenko, Mikhail" uniqKey="Ivanchenko M" first="Mikhail" last="Ivanchenko">Mikhail Ivanchenko</name></country><country name="France"><region name="Île-de-France"><name sortKey="Friguet, Bertrand" sort="Friguet, Bertrand" uniqKey="Friguet B" first="Bertrand" last="Friguet">Bertrand Friguet</name></region><name sortKey="Lemaitre, Jean Francois" sort="Lemaitre, Jean Francois" uniqKey="Lemaitre J" first="Jean-François" last="Lemaître">Jean-François Lemaître</name></country><country name="Grèce"><noRegion><name sortKey="Gonos, Efstathios S" sort="Gonos, Efstathios S" uniqKey="Gonos E" first="Efstathios S" last="Gonos">Efstathios S. Gonos</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Gut, Philipp" sort="Gut, Philipp" uniqKey="Gut P" first="Philipp" last="Gut">Philipp Gut</name></region></country><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Senior, Alistair M" sort="Senior, Alistair M" uniqKey="Senior A" first="Alistair M" last="Senior">Alistair M. Senior</name></region></country><country name="Allemagne"><noRegion><name sortKey="Simm, Andreas" sort="Simm, Andreas" uniqKey="Simm A" first="Andreas" last="Simm">Andreas Simm</name></noRegion></country><country name="Hong Kong"><noRegion><name sortKey="Vanhaelen, Quentin" sort="Vanhaelen, Quentin" uniqKey="Vanhaelen Q" first="Quentin" last="Vanhaelen">Quentin Vanhaelen</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Witkowski, Jacek M" sort="Witkowski, Jacek M" uniqKey="Witkowski J" first="Jacek M" last="Witkowski">Jacek M. Witkowski</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PoplarV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000294 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000294 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PoplarV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32693105
|texte= Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32693105" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |